Idebenone is an analogue of Coenzyme Q10.


In most respects, Idebenone shares its traits with Coenzyme Q10. Like Coenzyme Q10 is might be useful for aging. It differs from it in some important ways, which may make it more useful. Under certain circumstances, Coenzyme Q10 (CoQ10) may become a pro-oxidant. These circumstances are conditions in which hypoxia or lack of oxygen occurs. In cases of shock, heart attack, stroke, or poor circulation, CoQ10 auto-oxidizes and unleashes massive amounts of various free radicals that damage delicate tissues and because CoQ10 is necessary for electron transport and ATP (chemical energy) production, cellular death may ensue. Idebenone, on the other hand, suppresses free radicals and continues ATP production in hypoxic situations. This may make it a useful supplement for individuals at risk for those conditions.

Other important traits of Idebenone not shared by CoQ10 include the ability to raise the brain's serotonin levels like the SSRI antidepressants (Prozac) and it also increases the brain levels of nerve growth factor. Another trait is to protect the myelin sheath from damage as well as the mitochondria that has important implications in Multiple Sclerosis.

The ability to enhance serotonin production occurs even under less than optimal conditions such as those whose diet contains little L-Tryptophan.

Naturally, nerve growth is a desired result in many conditions. In Alzheimer's Disease, for example, several studies show dose dependent improvements when compared to placebo as measured by different tests when taking Idebenone. An abstract said, "Treatment with idebenone was found effective on memory, attention, and orientation and in slowing down the natural progressive worsening of the disease."

The following conditions may benefit from Idebenone: Brain enhancement as a nootropic, stroke, Alzheimer's, dementia, surgical candidates, cardiovascular, MS, other demyelination conditions, aging, depression, Friedreich's Ataxia, and liver problems.


Few adverse reactions have been noted with this substance even at doses of 900 mg daily.

Another description:

Idebenone is an analog (variation) of Coenzyme Q10, a powerful anti-oxidant biochemical known also as "ubiquinone" and most commonly as CoQ10. This substance is the energy producing unit of our body cells. Every process in our bodies requires CoQ10. Without CoQ10 life stops.

Idebenone supplies all of the same benefits as CoQ10 plus some distinct advantages based on its more complex chemical structure. Though very similar in chemical make-up to CoQ10, its longer chain organic structure gives it extra powerful anti-oxidant properties making it a more effective "free radical quencher" resulting in less cell and tissue damage.

Some leading doctors treating autism believe that Idebenone offers three very distinct advantages over CoQ10 in supplementing developmental disorders.